Molecular weight (DA)
59kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 156-206
Specificity
STAM1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011],
Function
function:Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.,PTM:Phosphorylated on Tyr-198. Phosphorylation occurs in response to IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF.,similarity:Belongs to the STAM family.,similarity:Contains 1 ITAM domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 UIM (ubiquitin-interacting motif) repeat.,similarity:Contains 1 VHS domain.,subunit:Com
Protein name
Signal transducing adapter molecule 1 (STAM-1)
Fields
>>Endocytosis;>>JAK-STAT signaling pathway
Human protein sequence Database
Q92783
Mouse protein sequence database
P70297
Rat protein sequence database
Cellular localization
Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
Tissue expression
Ubiquitously expressed.
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