Molecular weight (DA)
73kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 52-102
Specificity
URP2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010],
Function
domain:The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.,function:Probably involved in cell adhesion.,similarity:Belongs to the kindlin family.,similarity:Contains 1 FERM domain.,similarity:Contains 1 PH domain.,subcellular location:Membrane-associated in chronic lymphocytic leukemia (CLL) cells.,tissue specificity:Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.,
Gene Name
FERMT3 KIND3 MIG2B URP2
Protein name
Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2)
Fields
>>Platelet activation
Human protein sequence Database
Q86UX7
Mouse protein sequence database
Q8K1B8
Rat protein sequence database
Cellular localization
Cell projection, podosome . Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. .
Tissue expression
Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
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