Molecular weight (DA)
68kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 125-175
Specificity
TKT Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],
Function
catalytic activity:Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.,cofactor:Binds 1 calcium ion per subunit.,cofactor:Binds 1 thiamine pyrophosphate per subunit.,disease:Has been implicated in the latent genetic disease Wernicke-Korsakoff syndrome (WKS) [MIM:277730]. WKS causes specific brain damage.,online information:Transketolase entry,similarity:Belongs to the transketolase family.,subunit:Homodimer.,
Protein name
Transketolase (TK) (EC 2.2.1.1)
Fields
>>Pentose phosphate pathway;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids
Human protein sequence Database
P29401
Mouse protein sequence database
P40142
Rat protein sequence database
P50137
Cellular localization
nucleus,nucleoplasm,peroxisome,cytosol,vesicle,myelin sheath,extracellular exosome,
Tissue expression
Brain,Epithelium,Human uterus,Kidney,Liver,Lymph,Platelet,Thymus,
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