Molecular weight (DA)
186kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 1125-1175
Specificity
ITSN2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist,function:Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles.,miscellaneous:Overexpression results in the inhibition of the transferrin uptake and the blockage of the clathrin-mediated endocytosis.,similarity:Contains 1 C2 domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 2 EF-hand domains.,similarity:Contains 2 EH domains.,similarity:Contains 5 SH3 domains.,subunit:Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according to the step in the endocytic process.,tissue specificity:Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.,
Gene Name
ITSN2 KIAA1256 SH3D1B SWAP
Protein name
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Human protein sequence Database
Q9NZM3
Mouse protein sequence database
Q9Z0R6
Rat protein sequence database
Cellular localization
Cytoplasm.
Tissue expression
Expressed in melanocytes (PubMed:23999003). Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.
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