Molecular weight (DA)
41kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 130-210
Specificity
P2RY1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
purinergic receptor P2Y1(P2RY1) Homo sapiens The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008],
Function
function:Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.,induction:Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
P2Y purinoceptor 1 (P2Y1) (ATP receptor) (Purinergic receptor)
Fields
>>Rap1 signaling pathway;>>Neuroactive ligand-receptor interaction;>>Platelet activation;>>Taste transduction
Human protein sequence Database
P47900
Mouse protein sequence database
P49650
Rat protein sequence database
P49651
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Blood,Brain,Lung,Placenta,Platelet,
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