Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
LT4R1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.,PTM:Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.,
Function
function:Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.,PTM:Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.,
Gene Name
LTB4R BLT BLT1 BLTR CMKRL1 GPR16 P2RY7
Protein name
Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7)
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
Q15722
Mouse protein sequence database
O88855
Rat protein sequence database
Q9R0Q2
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.
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