Molecular weight (DA)
48kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 170-250
Specificity
DRD2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008],
Function
disease:Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.,disease:It has been suggested that DRD2 is involved in psychiatric disorders; especially in schizophrenia.,function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,polymorphism:Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism
Protein name
D(2) dopamine receptor (Dopamine D2 receptor)
Fields
>>Rap1 signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Dopaminergic synapse;>>Parkinson disease;>>Cocaine addiction;>>Alcoholism
Human protein sequence Database
P14416
Mouse protein sequence database
P61168
Rat protein sequence database
P61169
Cellular localization
Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .
Tissue expression
[Isoform 1]: Expressed in the anterior pituitary gland. ; [Isoform 2]: Expressed in the anterior pituitary gland.
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