Molecular weight (DA)
53kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 410-490
Specificity
CALCR Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009],
Function
function:This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.,polymorphism:Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.,similarity:Belongs to the G-protein coupled receptor 2 family.,subunit:Interacts with GPRASP2.,
Protein name
Calcitonin receptor (CT-R)
Fields
>>Neuroactive ligand-receptor interaction;>>Osteoclast differentiation
Human protein sequence Database
P30988
Mouse protein sequence database
Q60755
Rat protein sequence database
P32214
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Amygdala,Kidney,Mammary carcinoma,Ovarian carcinoma,Placenta,
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