Molecular weight (DA)
11kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 51-100
Specificity
DEF6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
defensin alpha 6(DEFA6) Homo sapiens Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014],
Function
function:Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.,similarity:Belongs to the alpha-defensin family.,subunit:Homodimer.,tissue specificity:Paneth cells of the small intestine.,
Protein name
Defensin-6 (Defensin, alpha 6)
Fields
>>NOD-like receptor signaling pathway;>>Staphylococcus aureus infection;>>Transcriptional misregulation in cancer
Human protein sequence Database
Q01524
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted . Cytoplasmic vesicle, secretory vesicle . Stored as propeptide in secretory granules of small intestinal Paneth cells and found in the ileum lumen as mature peptide. .
Tissue expression
Expressed in Paneth cells of the small intestine (at protein level).
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