Molecular weight (DA)
47kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 81-130
Specificity
RN135 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
ring finger protein 135(RNF135) Homo sapiens The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
Function
disease:Defects in RNF135 are the cause of RNF135-related overgrowth syndrome. RNF135-related overgrowth syndrome is characterized by overgrowth, learning disability, dysmorphic features and variable additional features.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,
Protein name
E3 ubiquitin-protein ligase RNF135 (EC 6.3.2.-) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (Riplet)
Human protein sequence Database
Q8IUD6
Mouse protein sequence database
Q9CWS1
Rat protein sequence database
Q5M929
Cellular localization
Cytoplasm . Cytoplasm, Stress granule .
Tissue expression
Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung.
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