Molecular weight (DA)
47kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 60-140
Specificity
LGMN Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.,function:Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.,PTM:Glycosylated.,similarity:Belongs to the peptidase C13 family.,tissue specificity:Ubiquitous. Particularly abundant in kidney, heart and placenta.,
Protein name
Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)
Fields
>>Lysosome;>>Antigen processing and presentation
Human protein sequence Database
Q99538
Mouse protein sequence database
O89017
Rat protein sequence database
Q9R0J8
Cellular localization
Lysosome .
Tissue expression
Ubiquitous. Particularly abundant in kidney, heart and placenta.
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