Molecular weight (DA)
130kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PTN14 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010],
Function
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta.,
Protein name
Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)
Human protein sequence Database
Q15678
Mouse protein sequence database
Q62130
Rat protein sequence database
Cellular localization
Cytoplasm. Cytoplasm, cytoskeleton . Nucleus. Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
Tissue expression
Ubiquitous.
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