Molecular weight (DA)
34kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 30-110
Specificity
TRML1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012],
Function
function:Cell surface receptor that may play a role in the innate and adaptive immune response.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subcellular location:Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis.,subunit:When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.,tissue specificity:Detected in platelets, monocytic leukemia and in T-cell leukemia.,
Gene Name
TREML1 TLT1 UNQ1825/PRO3438
Protein name
Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1)
Human protein sequence Database
Q86YW5
Mouse protein sequence database
Q8K558
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).
Tissue expression
Detected in platelets, monocytic leukemia and in T-cell leukemia.
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