Molecular weight (DA)
47kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 230-310
Specificity
TBX6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008],
Function
developmental stage:Expressed during gastrulation and during a second phase in some adult tissues.,function:Probable transcriptional regulator involved in developmental processes. Could be required for specification of paraxial mesoderm structures during gastrulation.,similarity:Contains 1 T-box DNA-binding domain.,subunit:Forms a dimeric complex with DNA (in vitro).,tissue specificity:Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus.,
Protein name
T-box transcription factor TBX6 (T-box protein 6)
Human protein sequence Database
O95947
Mouse protein sequence database
P70327
Rat protein sequence database
D3ZJK7
Cellular localization
Nucleus .
Tissue expression
Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus.
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