Molecular weight (DA)
45kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 350-430
Specificity
HEPS Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],
Function
catalytic activity:Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys.,function:Plays an essential role in cell growth and maintenance of cell morphology.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SRCR domain.,tissue specificity:Present in most tissues, with the highest level in liver.,
Protein name
Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain]
Fields
>>Viral carcinogenesis
Human protein sequence Database
P05981
Mouse protein sequence database
O35453
Rat protein sequence database
Q05511
Cellular localization
Cell membrane ; Single-pass type II membrane protein . Apical cell membrane ; Single-pass type II membrane protein .
Tissue expression
Detected in liver and kidney.
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