Molecular weight (DA)
87kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DPP10 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist, which may have different subcellular locations,caution:Gly-651 is present instead of the conserved Ser which is expected to be an active site residue.,disease:Defects in DPP10 may be a cause of susceptibility to asthma. Defects in splicing have been observed.,function:Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2.,PTM:N-glycosylated.,similarity:Belongs to the peptidase S9B family. DPPIV subfamily.,subunit:May form oligomers. Interacts with KCND1 (Probable). Interacts with KCND2.,tissue specificity:Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.,
Gene Name
DPP10 DPRP3 KIAA1492
Protein name
Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase IV-related protein 3) (DPRP-3) (Dipeptidyl peptidase X) (DPP X) (Dipeptidyl peptidase-like protein 2) (DPL2)
Human protein sequence Database
Q8N608
Mouse protein sequence database
Q6NXK7
Rat protein sequence database
Q6Q629
Cellular localization
Cell membrane ; Single-pass type II membrane protein .
Tissue expression
Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.
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