Molecular weight (DA)
15kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
C1D Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010],
Function
function:Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA. Forms a multi-subunit complex with MPP6 and EXOSC10 and this complex along with MTR4 is required for the 3'-5' end processing of the 5.8S rRNA. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a TP53/p53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB.,induction:By gamma-radiation.,PTM:Phosphorylated by PRKDC.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the C1D family.,subcellular location:EXOSC10 is required for nucleolar localization.,subunit:Monomer and homodimer. Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2 (By similarity). Interacts with EXOSC10. Forms a heterotrime
Protein name
Nuclear nucleic acid-binding protein C1D (hC1D)
Human protein sequence Database
Q13901
Mouse protein sequence database
O35473
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Nucleus, nucleolus . EXOSC10 is required for nucleolar localization (PubMed:17412707). Colocalizes with TSNAX in the nucleus (PubMed:11801738). .
Tissue expression
Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon.
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