Molecular weight (DA)
52kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DDC Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
dopa decarboxylase(DDC) Homo sapiens The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011],
Function
catalytic activity:3,4-dihydroxy-L-phenylalanine = dopamine + CO(2).,catalytic activity:5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2).,cofactor:Pyridoxal phosphate.,disease:Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.,function:Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.,online information:Aromatic L-amino-acid decarboxylase entry,pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopam
Protein name
Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC)
Fields
>>Tyrosine metabolism;>>Phenylalanine metabolism;>>Tryptophan metabolism;>>Metabolic pathways;>>Serotonergic synapse;>>Dopaminergic synapse;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism
Human protein sequence Database
P20711
Mouse protein sequence database
O88533
Rat protein sequence database
P14173
Cellular localization
cytosol,synaptic vesicle,axon,neuronal cell body,extracellular exosome,
Tissue expression
[Isoform 2]: High expression in kidney.
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