Molecular weight (DA)
63kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CARF Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
Function
function:Activates TP53/p53 by CDKN2A-dependent and CDKN2A-independent pathways.,PTM:May be ubiquitinated.,similarity:Belongs to the CARF family.,similarity:Contains 1 DRBM (double-stranded RNA-binding) domain.,subunit:Interacts with CDKN2A/p14ARF, TP53/p53 and MDM2.,tissue specificity:Ubiquitously expressed.,
Protein name
CDKN2A-interacting protein (Collaborator of ARF)
Human protein sequence Database
Q9NXV6
Mouse protein sequence database
Q8BI72
Rat protein sequence database
Q5U2X0
Cellular localization
Nucleus, nucleoplasm .
Tissue expression
Ubiquitously expressed.
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