Molecular weight (DA)
81kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PROX1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012],
Function
function:May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons.,similarity:Belongs to the Prospero homeobox family.,similarity:Contains 1 Prospero-type homeobox DNA-binding domain.,tissue specificity:Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.,
Protein name
Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1)
Human protein sequence Database
Q92786
Mouse protein sequence database
P48437
Rat protein sequence database
Cellular localization
Nucleus . RORG promotes its nuclear localization. .
Tissue expression
Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
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