Molecular weight (DA)
36kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
FHR1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009],
Function
function:Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.,PTM:N-glycosylated. Two forms are observed; one with a single side chain and the other with two.,similarity:Contains 5 Sushi (CCP/SCR) domains.,tissue specificity:Expressed by the liver and secreted in plasma.,
Gene Name
CFHR1 CFHL CFHL1 CFHL1P CFHR1P FHR1 HFL1 HFL2
Protein name
Complement factor H-related protein 1 (FHR-1) (H factor-like protein 1) (H-factor-like 1) (H36)
Fields
>>Complement and coagulation cascades
Human protein sequence Database
Q03591
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed by the liver and secreted in plasma.
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