Molecular weight (DA)
19kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TP4A1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
protein tyrosine phosphatase type IVA, member 1(PTP4A1) Homo sapiens This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013],
Function
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed in fetal liver.,enzyme regulation:Inhibited by sodium orthovanadate and pentamidine.,function:Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.,induction:Strongly down-regulated upon tetrodotoxin treatment.,PTM:Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subcellular location:And mitotic spindle.,subunit:Homotrimer. Interacts with ATF5 (By similarity). Inte
Gene Name
PTP4A1 PRL1 PTPCAAX1
Protein name
Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)
Human protein sequence Database
Q93096
Mouse protein sequence database
Q63739
Rat protein sequence database
Q78EG7
Cellular localization
Cell membrane ; Lipid-anchor . Early endosome . Endoplasmic reticulum . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Nucleus . And mitotic spindle. .
Tissue expression
Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
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