Molecular weight (DA)
311kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MXRA5 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010],
Function
developmental stage:Over-expressed in centenarians. Expression is reduced from young to old but increased from old to centenarians.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 12 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 7 LRR (leucine-rich) repeats.,
Protein name
Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican)
Human protein sequence Database
Q9NR99
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Highly expressed in kidney, also detected on liver and spleen (PubMed:27599751). Expressed by proximal tubular cells of the kidney (at protein level) (PubMed:27599751). Expression highly increases during chronic kidney disease and autosomal dominant polycystic kidney disease, where is detected in cysts (PubMed:27599751).
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