Molecular weight (DA)
24kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CREG1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008],
Function
function:May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.,PTM:N-glycosylated.,similarity:Belongs to the CREG family.,subunit:Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.,
Gene Name
CREG1 CREG UNQ727/PRO1409
Protein name
Protein CREG1 (Cellular repressor of E1A-stimulated genes 1)
Human protein sequence Database
O75629
Mouse protein sequence database
O88668
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Liver,Lymph,Placenta,
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