Molecular weight (DA)
15kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
GNLY Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Function
function:Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.,induction:By T-cell growth factor and interleukin-2.,PTM:A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.,similarity:Contains 1 saposin B-type domain.,subcellular location:Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.,tissue specificity:Expressed in natural killer and T-cells.,
Gene Name
GNLY LAG2 NKG5 TLA519
Protein name
Granulysin (Lymphokine LAG-2) (Protein NKG5) (T-cell activation protein 519)
Human protein sequence Database
P22749
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted. Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
Tissue expression
Expressed in natural killer and T-cells.
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