Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MXI1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008],
Function
disease:Defects in MXI1 are found in some patients with prostate cancer (CaP) [MIM:176807].,function:Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17.,tissue specificity:High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.,
Protein name
Max-interacting protein 1 (Max interactor 1) (Class C basic helix-loop-helix protein 11) (bHLHc11)
Human protein sequence Database
P50539
Mouse protein sequence database
P50540
Rat protein sequence database
O09015
Cellular localization
Nucleus.
Tissue expression
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
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