Molecular weight (DA)
20kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
REL1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
relaxin 1(RLN1) Homo sapiens Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013],
Function
function:Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.,similarity:Belongs to the insulin family.,subunit:Heterodimer of a B chain and an A chain linked by two disulfide bonds.,tissue specificity:Prostate. Not expressed in placenta, decidua or ovary.,
Protein name
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]
Fields
>>Neuroactive ligand-receptor interaction;>>Relaxin signaling pathway
Human protein sequence Database
P04808
Mouse protein sequence database
P47932
Rat protein sequence database
P01347
Cellular localization
Secreted.
Tissue expression
Prostate. Not expressed in placenta, decidua or ovary.
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