Molecular weight (DA)
101kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
EXTL3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012],
Function
catalytic activity:UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.,caution:It is uncertain whether Met-1, Met-6 or Met-20 is the initiator.,disease:Candidate gene for the breast cancer locus on chromosome 8p12-p22.,function:Probable glycosyltransferase.,online information:Exostosin-like 3,online information:GlycoGene database,pathway:Glycan metabolism; heparan sulfate biosynthesis.,similarity:Belongs to the glycosyltransferase 47 family.,tissue specificity:Ubiquitous.,
Gene Name
EXTL3 EXTL1L EXTR1 KIAA0519
Protein name
Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-lik
Fields
>>Glycosaminoglycan biosynthesis - heparan sulfate / heparin;>>Metabolic pathways
Human protein sequence Database
O43909
Mouse protein sequence database
Q9WVL6
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus .
Tissue expression
Ubiquitous. Expressed in keratinocytes.
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