Molecular weight (DA)
79kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DLL1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008],
Function
function:Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.,PTM:Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.,similarity:Contains 1 DSL domain.,similarity:Contains 8 EGF-like domains.,subunit:Interacts with Notch receptors.,tissue specificity:Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.,
Gene Name
DLL1 UNQ146/PRO172
Protein name
Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1)
Fields
>>Endocrine resistance;>>Notch signaling pathway;>>Th1 and Th2 cell differentiation;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Breast cancer
Human protein sequence Database
O00548
Mouse protein sequence database
Q61483
Rat protein sequence database
P97677
Cellular localization
Apical cell membrane ; Single-pass type I membrane protein . Cell junction, adherens junction . Membrane raft . Distributed around adherens junction in the apical endfeet through interactions with MAGI1. .
Tissue expression
Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.
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