Molecular weight (DA)
84kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SNRK Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-173 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,tissue specificity:Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.,
Gene Name
SNRK KIAA0096 SNFRK
Protein name
SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase)
Human protein sequence Database
Q9NRH2
Mouse protein sequence database
Q8VDU5
Rat protein sequence database
Q63553
Cellular localization
Nucleus .
Tissue expression
Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.
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