Molecular weight (DA)
95kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
E2F8 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012],
Function
domain:Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer.,function:Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Belongs to the E2F/DP family.,subunit:Forms heterodimers with E2F7 and, to a lesser extent, homodimers. Dimerization is important for DNA binding.,
Protein name
Transcription factor E2F8 (E2F-8)
Human protein sequence Database
A0AVK6
Mouse protein sequence database
Q58FA4
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Lung,Mammary gland,Skin,Testis,
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