Molecular weight (DA)
137kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
REV1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016],
Function
domain:The C-terminal domain is necessary for protein interactions.,function:Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.,similarity:Belongs to the DNA polymerase type-Y family.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 umuC domain.,subunit:Monomer. Binds MAD2L2, POLH, POLI, POLK and REV3L. May bind ITGA3.,tissue specificity:Ubiquitous.,
Protein name
DNA repair protein REV1 (EC 2.7.7.-) (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase)
Fields
>>Fanconi anemia pathway
Human protein sequence Database
Q9UBZ9
Mouse protein sequence database
Q920Q2
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Ubiquitous.
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