Molecular weight (DA)
66kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
KRT84 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. [provided by RefSeq, Jul 2008],
Function
caution:Maps to a duplicated region on chromosome 12.,miscellaneous:There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,tissue specificity:Expressed in the hair follicle.,
Protein name
Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)
Human protein sequence Database
Q9NSB2
Mouse protein sequence database
Q99M73
Rat protein sequence database
Cellular localization
keratin filament,extracellular exosome,
Tissue expression
Expressed in the hair follicles.
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