Molecular weight (DA)
44kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 120-200
Specificity
CCBE1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010],
Function
function:Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.,similarity:Belongs to the CCBE1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 2 collagen-like domains.,tissue specificity:Not expressed in blood or lymphatic endothelial cells.,
Gene Name
CCBE1 KIAA1983 UNQ1921/PRO4395
Protein name
Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein homolog)
Human protein sequence Database
Q6UXH8
Mouse protein sequence database
Q3MI99
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Not expressed in blood or lymphatic endothelial cells.
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