Molecular weight (DA)
21kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 140-220
Specificity
ARL11 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010],
Function
disease:Defects in ARL11 may be a cause of susceptibility to chronic lymphocytic leukemia (CLL) [MIM:151400].,function:May play a role in apoptosis. May act as a tumor suppressor.,similarity:Belongs to the small GTPase superfamily. Arf family.,tissue specificity:Expressed in lung and leukocytes.,
Protein name
ADP-ribosylation factor-like protein 11 (ADP-ribosylation factor-like tumor suppressor protein 1)
Human protein sequence Database
Q969Q4
Mouse protein sequence database
Q6P3A9
Rat protein sequence database
Q5BK71
Cellular localization
intracellular,
Tissue expression
Expressed in lung and leukocytes.
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