Molecular weight (DA)
73kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 100-180
Specificity
KAISO Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear impor
Function
function:Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.,induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 3 C2H2-type zinc fingers.,subcellular location:Also cytoplasmic in cells grown at high densities.,subunit:Self-associates. Interacts with CTNND2 (By similarity).
Gene Name
ZBTB33 KAISO ZNF348
Protein name
Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)
Human protein sequence Database
Q86T24
Mouse protein sequence database
Q8BN78
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Also cytoplasmic in cells grown at high densities.
Tissue expression
Expressed in vascular endothelium.
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