Molecular weight (DA)
93kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 430-510
Specificity
AKAP4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
developmental stage:Post-meiotic phase of spermatogenesis.,domain:RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.,function:Major structural component of sperm fibrous sheath. Plays a role in sperm motility.,similarity:Belongs to the AKAP110 family.,subcellular location:Localizes to the principle piece of the sperm flagellum.,subunit:Interacts with PRKAR1A and PRKAR2A.,tissue specificity:Testis specific; only expressed in round spermatids.,
Protein name
A-kinase anchor protein 4 (AKAP-4) (A-kinase anchor protein 82 kDa) (AKAP 82) (hAKAP82) (Major sperm fibrous sheath protein) (HI) (Protein kinase A-anchoring protein 4) (PRKA4)
Human protein sequence Database
Q5JQC9
Mouse protein sequence database
Q60662
Rat protein sequence database
O35774
Cellular localization
Cell projection, cilium, flagellum . Localizes to the principle piece of the sperm flagellum.
Tissue expression
Testis specific; only expressed in round spermatids.
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