Molecular weight (DA)
19kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 60-140
Specificity
CNBP Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016],
Function
disease:Defects in CNBP are the cause of myotonic dystrophy 2 (DM2) [MIM:602668]; also known as proximal myotonic myopathy (PROMM). DM2 is an autosomal dominant neurodegenerative disorder characterized by myotonia. DM2 is caused by a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.,function:Single stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.,similarity:Contains 7 CCHC-type zinc fingers.,tissue specificity:Present in all tissues examined.,
Gene Name
CNBP RNF163 ZNF9
Protein name
Cellular nucleic acid-binding protein (CNBP) (Zinc finger protein 9)
Human protein sequence Database
P62633
Mouse protein sequence database
P53996
Rat protein sequence database
P62634
Cellular localization
Nucleus . Cytoplasm . Endoplasmic reticulum .; [Isoform 1]: Cytoplasm .; [Isoform 2]: Cytoplasm .; [Isoform 4]: Cytoplasm .; [Isoform 5]: Cytoplasm .; [Isoform 6]: Cytoplasm .; [Isoform 8]: Cytoplasm .
Tissue expression
Expressed in the liver, kidney, spleen, testis, lung, muscle and adrenal glands.
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