Molecular weight (DA)
145kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 590-670
Specificity
JIP4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011],
Function
function:The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction.,induction:Isoform 3 is increased in systemic sclerosis fibroblasts.,PTM:Phosphorylated by MAPK8 and MAPK14 (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the JIP scaffold family.,subcellular location:Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.,subcellular location:Perinuclear distribution in response to stress signals such as UV radiation.,subunit:Homo-oligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8.
Gene Name
SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6
Protein name
C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper pr
Human protein sequence Database
O60271
Mouse protein sequence database
Q58A65
Rat protein sequence database
Cellular localization
Cytoplasm . Cytoplasm, perinuclear region . Lysosome membrane . Perinuclear distribution in response to stress signals such as UV radiation. .; [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome . Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix. .
Tissue expression
Expressed only in testis on the round spermatids of stage I, II and II. Absent in spermatogonia and spermatocyte. ; [Isoform 4]: Expressed in testis and in acute myeloid leukemia (AML) patients. ; [Isoform 3]: Expressed in testis.
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