Molecular weight (DA)
80kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 510-590
Specificity
CCNT2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010],
Function
function:Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).,similarity:Belongs to the cyclin family. Cyclin C subfamily.,subunit:Associates with CDK9 to form P-TEFb. Isoform A and isoform B interact with HIV-2 and SIV Tat. Does not bind efficiently to the transactivation domain of the HIV-1 Tat.,tissue specificity:Ubiquitously expressed.,
Protein name
Cyclin-T2 (CycT2)
Fields
>>Viral life cycle - HIV-1;>>Transcriptional misregulation in cancer
Human protein sequence Database
O60583
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm, perinuclear region . Nucleus . Nucleus in differentiating cells. .
Tissue expression
Ubiquitously expressed.
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