Molecular weight (DA)
81kD
Immunogen
Synthesized peptide derived from part region of human protein. AA range 30-80
Specificity
SV2A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. [provided by RefSeq, Jun 2016],
Function
function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.,miscellaneous:Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev.,PTM:N-glycosylated.,PTM:Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.,similarity:Belongs to the major facilitator superfamily.,subcellular location:Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.,subunit:Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2.,
Gene Name
SV2A KIAA0736 PSEC0174
Protein name
Synaptic vesicle glycoprotein 2A
Fields
>>ECM-receptor interaction
Human protein sequence Database
Q7L0J3
Mouse protein sequence database
Q9JIS5
Rat protein sequence database
Q02563
Cellular localization
Cell junction, synapse, presynapse . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. .
Tissue expression
Brain,Brain cortex,Ovary,Retina,Teratocarcinoma,
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