Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SOAT1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011],
Function
catalytic activity:Acyl-CoA + cholesterol = CoA + cholesterol ester.,disease:Accumulation of insoluble cholesterol esters in macrophages and smooth muscle is a characteristic feature of early lesions of atherosclerotic plaque.,function:Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.,induction:Highly activated by the presence of cholesterol.,similarity:Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.,subunit:May form homo- or heterodimers.,
Gene Name
SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STAT
Protein name
Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
Fields
>>Steroid biosynthesis;>>Cholesterol metabolism
Human protein sequence Database
P35610
Mouse protein sequence database
Q61263
Rat protein sequence database
O70536
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue expression
Macrophage,Placenta,
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