Molecular weight (DA)
129kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SL9C1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family (see SLC9A1, MIM 107310) and is required for male fertility and sperm motility (Wang et al., 2003 [PubMed 14634667]).[supplied by OMIM, Apr 2009],
Function
domain:The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown.,function:Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC).,similarity:Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:Interacts with soluble adenylyl cyclase (sAC).,
Protein name
Sodium/hydrogen exchanger 10 (Na(+)/H(+) exchanger 10) (NHE-10) (Solute carrier family 9 member 10) (Solute carrier family 9 member C1) (Sperm-specific Na(+)/H(+) exchanger) (sNHE)
Human protein sequence Database
Q4G0N8
Mouse protein sequence database
Q6UJY2
Rat protein sequence database
Cellular localization
Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein .
Tissue expression
Testis,
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