Molecular weight (DA)
16kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 30-110
Specificity
CCL25 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014],
Function
function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1.,online information:CCL25 entry,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.,
Gene Name
CCL25 SCYA25 TECK
Protein name
C-C motif chemokine 25 (Chemokine TECK) (Small-inducible cytokine A25) (Thymus-expressed chemokine)
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>Intestinal immune network for IgA production
Human protein sequence Database
O15444
Mouse protein sequence database
O35903
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.
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