Molecular weight (DA)
106kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PLK4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:May play a role in cell proliferation.,PTM:Tyrosine-phosphorylated by TEC.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.,similarity:Contains 1 POLO box domain.,similarity:Contains 1 protein kinase domain.,
Protein name
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Fields
>>FoxO signaling pathway
Human protein sequence Database
O00444
Mouse protein sequence database
Q64702
Rat protein sequence database
B2GUY1
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Nucleus, nucleolus . Cleavage furrow . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.
Tissue expression
Blood,Lung,Testis,
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