Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 140-220
Specificity
RND1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014],
Function
function:Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.,similarity:Belongs to the small GTPase superfamily. Rho family.,subunit:Binds GRB7 and PLXNB1. Interacts with UBXD5.,tissue specificity:Mostly expressed in brain and liver.,
Protein name
Rho-related GTP-binding protein Rho6 (Rho family GTPase 1) (Rnd1)
Human protein sequence Database
Q92730
Mouse protein sequence database
Q8BLR7
Rat protein sequence database
Cellular localization
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytoskeleton .
Tissue expression
Mostly expressed in brain and liver.
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