Molecular weight (DA)
18kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 80-160
Specificity
TIG3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008],
Function
function:May be a growth regulator that mediates some of the growth suppressive effects of retinoids.,induction:By tazarotene.,similarity:Belongs to the H-rev107 family.,tissue specificity:Expressed in many tissues. Not expressed in heart, brain, and testis.,
Gene Name
RARRES3 RIG1 TIG3
Protein name
Retinoic acid receptor responder protein 3 (EC 3.1.1.-) (RAR-responsive protein TIG3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein)
Human protein sequence Database
Q9UL19
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane ; Single-pass membrane protein .
Tissue expression
Widely expressed.
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