Molecular weight (DA)
24kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Specificity
RAB32 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015],
Function
function:Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission.,similarity:Belongs to the small GTPase superfamily. Rab family.,tissue specificity:Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.,
Protein name
Ras-related protein Rab-32
Human protein sequence Database
Q13637
Mouse protein sequence database
Q9CZE3
Rat protein sequence database
Cellular localization
Mitochondrion . Mitochondrion outer membrane ; Lipid-anchor . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Melanosome . Melanosome membrane . Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991). .
Tissue expression
Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.
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