Molecular weight (DA)
66kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 230-310
Specificity
GDS1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010],
Function
function:Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.,similarity:Contains 5 ARM repeats.,
Protein name
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Human protein sequence Database
P52306
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Endoplasmic reticulum . Mitochondrion . Nucleus . Nuclear import is dependent on complexing with a GTPase containing a C-terminal polybasic region. .
Tissue expression
Brain,Muscle,PCR rescued clones,Peripheral blood,
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