Molecular weight (DA)
335kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1280-1360
Specificity
BD1L1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM.
Gene Name
BOD1L1 BOD1L FAM44A KIAA1327
Protein name
Biorientation of chromosomes in cell division protein 1-like 1 (Protein FAM44A)
Human protein sequence Database
Q8NFC6
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Chromosome . Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection. .